Doubts cast on pre-eclampsia prophylaxis in women with diabetes
Evidence is emerging that low-dose aspirin may raise the risk of pre-eclampsia in these mothers-to-be, endocrinologists say
Far from reducing the risk of pre-eclampsia, taking low-dose aspirin may raise risk of the condition in pregnant women with diabetes, Australian researchers report.
The findings have implications for guidelines recommending universal low-dose aspirin prophylaxis in pregestational diabetes, they say.
Their retrospective cohort study was carried out in all 716 women with pregestational diabetes (type one and type two) delivering live singleton infants at the King Edward Memorial Hospital in Perth between 2013 and 2017.
Three quarters of the women were considered high-risk for pre-eclampsia, with low-dose aspirin being prescribed — at their treating doctor’s discretion — to 41% of the cohort, commencing at a median gestation of 10 weeks.
