Early tranexamic acid cuts deaths from brain injury

Time and severity of injury need to be taken into account, researchers say

Early infusion of tranexamic acid in patients with mild to moderate traumatic brain injury saves lives, according to the results of a large clinical trial.

doctor looking at CT head

The trial, known as CRASH-3, was carried out in 175 hospitals across 29 countries, and randomised 12,737 adults presenting to EDs with traumatic brain injury to either infusion of the antifibrinolytic or saline placebo.

Patients had a Glasgow Coma Scale (GCS) of 12 or below, or CT evidence of intracranial bleeding, but had no extracranial bleeding, the authors