Experts warn against routine paralytics in ARDS
![Person in ICU on ventilation](https://www.ausdoc.com.au/wp-content/uploads/2022/08/intensive_care_ventilator_dreamstime_s_97585783-1.jpg)
In patients on mechanical ventilation for moderate-to-severe adult respiratory distress syndrome (ARDS), early continuous neuromuscular blockade does not reduce mortality compared with a usual care approach with lighter sedation, clinical trial results show.
In the ROSE trial of more than 1000 patients with moderate-to-severe ARDS, US researchers evaluated the efficacy and safety of early neuromuscular blockade with cisatracurium infusion and concomitant heavy sedation for 48 hours.