Fewer colectomies for ulcerative colitis

Biologics appear to have 'changed the natural history' of the disease, say researchers

The rate of colectomy within the first year after hospital admission for ulcerative colitis has declined, suggesting the advent of biologic therapy has changed the natural history of the disease, researchers report.


US researchers used data from the Northern California Kaiser Permanente database to study 524 adults with ulcerative colitis and a first hospitalisation between 2009 and 2017.

Results showed that 5.3% of patients underwent colectomy during their first hospitalisation for ulcerative colitis and 11.9% had