First-line romosozumab ‘safe’ in severe osteoporosis

The US Endocrine Society has added the agent to its guidelines for therapy for postmenopausal women
X-ray of hip fracture

Postmenopausal women with severe osteoporosis can safely be prescribed the anabolic drug romosozumab as a first-line therapy, according to updated guidance from the US Endocrine Society.

The peak body made the decision to add the drug to its guidelines after reviewing a meta-analysis and two large clinical trials assessing its efficacy against placebo and the osteoporosis drug alendronate.