Gonadotropins 'no benefit' in unexplained infertility
Trial evidence does not support their use compared with oral agents, researchers say
5th February 2020
By Clare Pain
Women with unexplained infertility undergoing intrauterine insemination would do better to take oral ovarian stimulation agents than to use gonadotropins, say the authors of a meta-analysis.
The US researchers used data from eight randomised clinical trials, including nearly 3000 patients, to compare outcomes in women using gonadotropins with those in women taking the oral agents clomiphene and letrozole.
Five studies (including 2098 patients) reported the desired outcome