Gonadotropins 'no benefit' in unexplained infertility

Trial evidence does not support their use compared with oral agents, researchers say

Women with unexplained infertility undergoing intrauterine insemination would do better to take oral ovarian stimulation agents than to use gonadotropins, say the authors of a meta-analysis.

Histology of ovary with developing follicles

The US researchers used data from eight randomised clinical trials, including nearly 3000 patients, to compare outcomes in women using gonadotropins with those in women taking the oral agents clomiphene and letrozole.

Five studies (including 2098 patients) reported the desired outcome

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