High-dose flu shot may be best in RA

A trial has shown good response in patients under 65

Patients with rheumatoid arthritis (RA) may fare better with high-dose trivalent influenza vaccine rather than standard-dose quadrivalent vaccine, according to findings from a randomised controlled trial.

Flu shot

The study compared the immunogenicity and safety of standard dose quadrivalent inactivated vaccine (SD-QIV with 15μg haemagglutinin per strain) with high-dose trivalent vaccine (HD-TIV with 60μg per strain) in adults with RA at three hospitals affiliated with McGill University, Canada.

Some 279 trial participants (mean age about 60; 80% women and mostly white)