IBD-associated colorectal cancer 'differs from sporadic CRC'
Colorectal cancers (CRC) that evolve from inflammatory bowel disease (IBD) are genetically distinct from sporadic CRC, a study shows.
The findings may be relevant to prognosis and, eventually, to treatment options, the investigators say.
The team from Finland used whole-genome sequencing, single-nucleotide polymorphism arrays, RNA sequencing, genome-wide methylation analysis and immunohistochemistry to analyse tumour tissue and corresponding normal tissue from 31 patients with IBD who had developed CRC.
"Strikingly, the epithelial tumour subtype