Later menopause onset linked to lower risk of frailty: review

Maintenance of oestrogen may be a key factor, researchers say, but evidence in the literature is limited

Later age at menopause is associated with a reduced risk of prevalent frailty, with the delay in hormonal changes thought to play a pivotal protective role, a new analysis shows.

Results from the first systematic review and meta-analysis of its kind suggest that for each one-year increase in age of menopause onset, there is a 2% lower risk of prevalent frailty.

 “These findings enhance our understanding of pathophysiology of frailty development and, possibly, sex disparity of frailty,”

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