Leukaemia drug wins head-to-head for relapsing MS

The monoclonal antibody is associated with reduced odds of disability progressing, researchers say

Head-to-head comparisons show the monoclonal antibody ofatumumab is associated with a lower relapse rate than teriflunomide in patients with relapsing-remitting multiple sclerosis (MS).

woman in wheelchair

Two studies with identical protocols — the ASCLEPIOS trials I and II initiated and funded by oftumumab manufacturer Novartis — were carried out in 927 and 955 patients, respectively, across 385 centres in 37 countries from 2016-18.

Participants had a mean age of 38 years, two thirds were female, 94% had relapsing-remitting MS while the

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