Lithium risk-benefit in pregnancy favourable: study

Researchers emphasise dose titration, particularly in the first trimester

Lithium treatment for bipolar disorder should not be considered an absolute contraindication during pregnancy, as the risks from its use are relatively low, researchers say.

Pregnant woman

However, the international team recommends that pregnancy should be planned during remission and that lithium is prescribed within the lowest therapeutic range, particularly during the woman’s first trimester and immediately before delivery.

The group has conducted a systematic review and meta-analysis to ‘resolve uncertainties’ around balancing the need to prevent