Low-dose rituximab 'dampens disease activity' in pemphigus

Australian dermatologists report a case series of eight patients with mild disease

Patients with recalcitrant pemphigus may respond to ultra-low-dose rituximab, dermatologists say.

Nurse and doctor setting up IV

Six of eight patients treated at Royal Melbourne Hospital responded to two off-label 200mg doses, given a fortnight apart, with clinically significant reduced disease activity at six months, they report.

In a research letter to the British Journal of Dermatology, the doctors retrospectively reviewed the cases, all of whom had either recalcitrant