Low-dose tamoxifen halves recurrence of in situ breast cancer

The finding is practice-changing for women who are unable to tolerate the full dose, says researcher

Tamoxifen at a low dose reduces local and contralateral recurrence of breast intraepithelial neoplasia, according to a new randomised controlled trial.

woman in pink bra with ribbon on strap denoting breast cancer

Italian researchers randomly assigned 500 women aged 75 or younger with in situ breast cancers to receive tamoxifen 5mg or placebo for three years after surgery.

During follow-up of a median of 5.1 years, 14 neoplastic events occurred in the tamoxifen group, compared with 28 in the placebo group.

There were three contralateral breast events