Metastatic prostate cancer subtypes 'prognostic'

Researchers have demonstrated that patients with castration-resistant disease fall into luminal and basal subtypes and these respond differently to therapy

Basal and luminal subtypes of prostate cancer, well known in primary tumours, also exist in metastases and likely shape therapeutic outcomes, US researchers report.

The finding brings closer the prospect of personalised treatment for metastatic castration-resistant prostate cancer (mCRPC), “the lethal form of the disease”, they wrote in JAMA Oncology.

One of the problems with determining the nature of metastases in prostate cancer is that, because they are often