Methotrexate 'hinders immune response' to mRNA vaccine
The drug appears to interfere with both humoral and T-cell response, researchers say
Up to one-third of patients with immune-mediated inflammatory diseases taking methotrexate failed to achieve an adequate humoral or cellular immune response to Pfizer's mRNA COVID-19 vaccine in a small observational study.
Doctors analysed the immune response after a second dose of the vaccine in 82 patients with autoimmune or immune-modulated diseases in two cohorts — one at NYU Langone Health, New York, US and one in Erlangan, Germany.
The findings in the patients (who mainly had