Methotrexate 'hinders immune response' to mRNA vaccine

The drug appears to interfere with both humoral and T-cell response, researchers say

Up to one-third of patients with immune-mediated inflammatory diseases taking methotrexate failed to achieve an adequate humoral or cellular immune response to Pfizer's mRNA COVID-19 vaccine in a small observational study.

Pfizer vax, syringe and mask

Doctors analysed the immune response after a second dose of the vaccine in 82 patients with autoimmune or immune-modulated diseases in two cohorts — one at NYU Langone Health, New York, US and one in Erlangan, Germany.

The findings in the patients (who mainly had

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