More bronchiectasis patients benefit from macrolides

Current European guidelines should not be seen as ‘strict rules’, study suggests

Long-term use of macrolides for bronchiectasis can reduce and delay exacerbations and improve quality of life even in patients currently excluded in guidelines, a meta-analysis shows.

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Data for individual participants in three high-quality randomised controlled trials comparing at least three months of a macrolide use with placebo was reanalysed – effectively making a larger randomised controlled trial with 341 participants.

One of the studies included was the Australian BLESS trial of erythromycin vs placebo. The other two trials, including

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