Most acral melanomas 'likely don't arise from naevi'

The lesions have different underlying mutations, a genetic sequencing study reveals

Genetic analysis of the largest series of acral naevi specimens to date suggests that the lesions do not lead to prototypical acral melanomas, US researchers claim.

acral melanoma on heel

Their results suggest acral naevi and acral melanomas have different mutation patterns.

Acral naevi have a high rate of BRAF V6OOE mutations that can lead to cutaneous melanomas with exposure to UV rays in a small subset of patients, but acral melanoma has an entirely different mutation pathway.