Neoadjuvant chemo 'safe for locally advanced colon cancer'

More than half of patients demonstrate a histological response, investigators say

Chemotherapy ahead of resection increases the likelihood of clear surgical margins in locally advanced colon cancer compared with surgery upfront, Australian researchers have found.

Man having chemotherapy

Their study, believed to be the first meta-analysis to examine the issue, also showed no increase in adverse outcomes, including toxicity.

Firstly, the team carried out a systematic review of the literature from 2000 to 2020, finding eight studies that included a total of 752 patients with locally advanced