Neonatal seizures: Ceasing AEDs pre-discharge 'safe for most'

The largest observational study to date provides reassurance, US researchers say

For most newborns with acute symptomatic seizures, doctors can safely stop antiepileptic drugs (AEDs) before hospital discharge without worse outcomes, US researchers say.

nurses and babies in neonatal unit

The research team analysed data for 303 neonates with acute symptomatic seizures treated at nine US Neonatal Seizure Registry centres during a period of about three years.

They compared the effectiveness of discontinuing versus maintaining antiseizure therapy —