Neuroinflammation common in familial frontotemporal dementia

The findings bring hope that drugs that reduce neuroinflammation might be beneficial, researchers say

Neuroinflammation appears to be a typical feature of the three most common monogenic forms of familial frontotemporal dementia (FTD), according to a UK case series.

Man standing behind his wife with dementia

Researchers from the University of Cambridge used PET with a specific radioligand, [11C]PK11195, which binds to activated microglia and measures neuroinflammation, in seven patients with symptomatic familial FTD from MAPT, GRN or C9orf72 gene mutations.

One fifth of FTD cases are autosomal dominant and