Neuroinflammation common in familial frontotemporal dementia
The findings bring hope that drugs that reduce neuroinflammation might be beneficial, researchers say
Neuroinflammation appears to be a typical feature of the three most common monogenic forms of familial frontotemporal dementia (FTD), according to a UK case series.
Researchers from the University of Cambridge used PET with a specific radioligand, [11C]PK11195, which binds to activated microglia and measures neuroinflammation, in seven patients with symptomatic familial FTD from MAPT, GRN or C9orf72 gene mutations.
