Transvaginal mesh hysteropexy has not been shown to be superior to vaginal hysterectomy for treatment of uterovaginal prolapse in a randomised clinical trial.

US investigators report three-year outcomes for a group of postmenopausal women (mean age 66) with symptomatic uterovaginal prolapse who underwent vaginal mesh hysteropexy (88 women) or vaginal hysterectomy with uterosacral ligament suspension (87 women) as part of the SUPeR trial conducted at nine centers.

The vaginal mesh operation was 12 percentage points better than the hysterectomy but this was not statistically significant, the researchers said.

“Imprecision in study results precludes a definitive conclusion, and further research is needed to assess whether vaginal mesh hysteropexy is more effective than vaginal hysterectomy with uterosacral ligament suspension.”