No evidence on MRI that intensive BP control cuts Alzheimer’s risk: study
Further results from the SPRINT MIND trial show a 'counterintuitive' association with decreased hippocampal volume
Intensive blood pressure control does not lead to clinically meaningful differences in brain imaging biomarkers of Alzheimer’s disease on MRI, according to data from a US trial.
In fact, for one biomarker — hippocampal volume — those in the intensive BP control arm fared worse, with a statistically significant decrease at the four-year follow-up.
The researchers evaluated MRI brain scans obtained at baseline and at follow-up in a subset of some 450 of the 9000-plus participants in the SPRINT MIND trial.
All were aged over 50 at baseline (mean age 67) with clinical or subclinical CVD, but no dementia, the researchers wrote in JAMA Neurology.
