One dose of THC 'can trigger psychiatric symptoms in healthy adults'

Researchers carried out a systematic review of 15 studies in people without pre-existing psychosis

A single dose of tetrahydrocannabinol (THC), the psychoactive component in cannabis, may induce psychotic, depressive and anxiety symptoms in healthy adults, according to a systematic review.

Person rolling a joint

UK researchers examined 15 studies, including 331 people with no history of psychotic or other major psychiatric disorders.

The studies investigated participants' psychiatric symptoms following acute administration of IV, oral or nasal THC, cannabidiol (CBD) and placebo, as measured by the Brief Psychiatric Rating Scale and the