Oral glucocorticoids plus NOACs ‘nearly doubles GI bleeding risk’

The combination of drugs is common, and there is a dose-response relationship, researchers say

Treatment with concomitant non-vitamin K antagonist oral anticoagulants (NOACs) and oral glucocorticoids is associated with an elevated risk of gastrointestinal bleeds, according to findings from one of the few major studies to explore the issue, cardiologists say.

The results suggest that patients prescribed the dual therapy may require close monitoring, particularly those with an increased susceptibility to bleeding and on high doses of the steroids, the researchers say.