Parkinson's: no benefit in early levodopa
Giving patients with Parkinson’s disease levodopa earlier than their clinical symptoms warrant provides no extra benefit, a Dutch study suggests.
The researchers set out to determine whether the drug worked merely by reducing symptoms, or whether it had a true disease-modifying effect.
Research in 2004 had been equivocal, on the one hand suggesting that levodopa might slow disease progression but also providing brain-imaging evidence suggesting treatment with the drug accelerated dopamine neuron degeneration.
In the current study 445 patients, mean