PCOS: Metformin might benefit overweight women using IVF
The drug is associated with fewer complications and a higher pregnancy rate, researchers say
Metformin treatment might benefit women with PCOS and a BMI of 26 or greater who are undergoing assisted reproduction, a meta-analysis suggests.
The medication is widely used in women with PCOS but its associations with outcomes of IVF or intracytoplasmic sperm injection and embryo transfer (ICSI-ET) remain controversial, the researchers note in JAMA Network Open.
Chinese researchers performed a meta-analysis of 12 randomised trials that enrolled 1123 women with PCOS undergoing IVF or ICSI-ET and compared therapy with metformin against placebo.
Ovarian hyperstimulation syndrome, clinical pregnancy rate and live birth rate were the outcomes of interest.
