Polygenic risk score may predict sudden death in some CAD patients
Being in the top decile for the genome-wide polygenic score for coronary artery disease is associated with an increased risk for sudden and/or arrhythmic death among coronary artery disease patients without severe systolic dysfunction, according to a study published in the 30 August issue of the Journal of the American College of Cardiology.
Roopinder K Sandhu, MD, MPH, from the Cedars-Sinai Medical Center in Los Angeles, and colleagues examined whether a genome-wide polygenic score for coronary artery disease (GPSCAD) would have utility in sudden and/or arrhythmic death (SAD) risk stratification in 4698 CAD patients without severe systolic dysfunction.
The cohort was dichotomised according to top GPSCADÂ decile, as defined by the general population.
The researchers found that participants in the top GPSCAD decile were at elevated absolute SAD risk (8.0% vs 4.8%) and proportional SAD risk (29% vs 16%) compared with the rest of the participants during a median follow-up of eight years.