Polygenic risk score may predict sudden death in some CAD patients
High GPSCAD may predict sudden and/or arrhythmic death in patients with coronary artery disease without severe systolic dysfunction
Being in the top decile for the genome-wide polygenic score for coronary artery disease is associated with an increased risk for sudden and/or arrhythmic death among coronary artery disease patients without severe systolic dysfunction, according to a study published in the 30 August issue of the Journal of the American College of Cardiology.
Roopinder K Sandhu, MD, MPH, from the Cedars-Sinai Medical Center in Los Angeles, and colleagues examined whether a genome-wide polygenic score for coronary artery disease (GPSCAD) would have utility in sudden and/or arrhythmic death (SAD) risk stratification in 4698 CAD patients without severe systolic dysfunction.
