PPIs linked with gastric cancer 'regardless of H.pylori'

The study suggests risk rises with longer-term use, the researchers say

Taking PPIs is associated with increased risk of developing gastric cancer regardless of Helicobacter pylori eradication status, according to findings from Korea, a country with a high prevalence of the malignancy.

person holding yellow pill - PPI

Researchers examined data in the Korean National Health Insurance Service database on 6877 patients who initiated PPI therapy and the same number of propensity-matched controls who didn't use PPIs.

During a median follow-up of 4.3 years, 118 patients in the PPI group developed gastric cancer,