Prednisone can help prevent episodic cluster headache

'This is the study that everyone's been waiting for,' says study author

Prednisone is better than placebo for short-term prevention of episodic cluster headaches and should be used as first-line treatment along with verapamil up-titration, according to a new multicentre, randomised controlled trial.

Investigators at 10 headache centres across Germany randomised 116 patients with episodic cluster headache to 100mg of oral prednisone for five days and 20mg tapering every three days, for a total of 17 days of drug exposure, or a placebo.

All patients (ages 18-65, mean age 41, 83% male) were within