Primary and recurrent breast tumours 'may differ in HER2 status'

Some 15% of HER2-negative primary tumours switch to HER2 low status on relapse, researchers find

Human epidermal growth factor (HER2)-negative primary breast tumours may evolve to express low HER2 upon relapse, highlighting the need to retest recurrent tumours for HER2 expression, researchers say.

Woman in pink t-shirt with pink ribbon, denoting breast cancer

"The results provide a whole new insight on how HER2-low tumours might evolve as a subgroup, possibly challenging the current dichotomy between HER2-positive and HER2-negative breast cancer," Dr Federica Miglietta, of the University of Padua in Italy, said in a statement from the ESMO Breast Cancer Virtual

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