Questions over maximum methylphenidate doses for ADHD

Having an authorised dose range may be leading to undertreatment, say researchers

There appears to be no scientific rationale for published maximum doses of methylphenidate for treatment of ADHD in children and adolescents, according to an Australian meta-analysis.

Angry boy ADHD

Researchers from Sydney University and Western Sydney University investigated the doses used in published studies in their systematic review of 49 articles, including 11 randomised controlled trials (RCTs) and 38 cohort studies of children up to the age of 18 with ADHD who were dosed by titration.

In the included studies, maximum doses of methylphenidate ranged from 20mg/day to 72mg/day

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