Retinal imaging may predict familial Alzheimer’s disease

Study in a Colombian kindred with a dominant mutation showed pathology visible in patients' 30s
Reuters Health Staff writer
DNA, genes

Retinal alterations visible with optical coherence tomography (OCT) in carriers of familial Alzheimer’s disease may presage cognitive decline, according to a cross-sectional study.

US researchers studied 10 carriers of the presenilin 1 (PSEN1) E280A mutation who were cognitively unimpaired and 10 healthy family members without the mutation.