Review reveals top drugs for weight loss

But the leading agents also have the most challenging profiles for adverse events, researchers say

Phentermine-topiramate and glucagon-like peptide-1 receptor agonists are the most effective pharmacotherapies for adults with overweight and obesity, leading to bodyweight reductions of 6-11%, a large review shows.

The findings should facilitate optimal, evidence-based decision-making for patients and clinicians when considering weight loss interventions, the Chinese-led researchers say, although they note the most effective agent is approved for the indication only in the US.

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