Rheumatoid factor-negative cases of RA on the rise
Clinicians should be aware of the changing epidemiology of the disease, say researchers

More patients with rheumatoid arthritis (RA) are presenting negative for rheumatoid factor (RF) compared with past decades, a study shows.
A US team says doctors should be aware of the changing epidemiology of the disease with more RF-negative cases and declining seropositive cases.