Roche study flop marks yet another Alzheimer's drug setback

Investigational agent crenezumab failed to slow or prevent disease progression, company says

An experimental Alzheimer’s drug has failed to meaningfully slow or prevent cognitive decline in people at risk of an inherited form of the disease, marking another setback for clinical research.

Last week, Swiss pharmaceuticals giant Roche announced that its novel agent crenezumab did not meet the primary endpoints in a crucial phase II placebo-controlled trial.

“We’re disappointed that the treatment did not demonstrate a statistically significant clinical benefit,” Dr Eric Reiman, one of the study

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