Severe COVID-19 more likely in those with dementia alleles

UK Biobank study shows homozygous carriers have more than twice the risk of other common genotypes

Homozygosity for the apolipoprotein E ε4 (ApoE ε4) genotype appears to be associated with a higher rate of COVID-19, a study shows.

Vial of blood for genetic testing

UK and US researchers evaluated the association between ApoE ε4 alleles and severe COVID-19, with testing largely restricted to UK hospital inpatients with clinical signs of severe infection.

Pre-existing dementia had already been shown to be a risk factor for severe COVID-19, the researchers said.

Being homozygous for ApoE&nbsp