SGLT2 inhibitors beat sulfonylureas in reducing mortality: study

The real-world data also finds a survival benefit in staying on metformin and adding an SGLT2 inhibitor rather than using gliflozin monotherapy

Patients with type 2 diabetes treated with metformin have a better chance of living longer if they add an SGLT2 inhibitor rather than a sulfonylurea as second-line therapy, a large cohort study shows.

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Furthermore, the combination of metformin and an SGLT2 inhibitor reduces all-cause mortality by 30% compared with SGLT2 treatment alone.

The researchers from St Louis University, Missouri, used data from 2016-2021 for more than 128,000 US veterans with type 2 diabetes