Some young women presenting with psychosis may have primary Sjogren’s syndrome, according to US paediatric rheumatologists.

The group of doctors have published the case histories of four adolescent females aged between 16 and 19, all of whom failed to respond adequately to psychiatric therapy for psychosis.

Two of the teens were later definitively diagnosed with primary Sjogren’s syndrome, meeting the 2017 ACR-EULAR criteria for the condition.

The other two had serology positive for anti-Sjogren’s syndrome type A (anti-SSA) antibodies but did not consent to salivary gland testing; hence, the diagnosis of Sjogren’s could not be confirmed.