Study confirms neurodevelopmental risk with anti-epileptics

Nordic registry-based study implicates valproate and topiramate in childhood risk of ASD and intellectual disability
Reuters Health

Prenatal exposure to certain anti-epileptic medications and combinations are associated with a near fourfold increased risk of neurodevelopmental disorders, a large registry-based study confirms.

According to the Nordic researchers, topiramate exposure was associated with roughly triple the risk of autism spectrum disorder (ASD) and intellectual disability compared to no exposure, and valproate was linked to more than double the risk.