Study 'offers new insight' on neuropathogenesis of COVID-19

If confirmed, the findings would have implications for the treatment of patients, researchers say

SARS-CoV-2 viral antigens may contribute to central nervous system immune responses without direct viral invasion of the CNS, new data suggest.

It is now known that patients with COVID-19 may develop neurologic symptoms but it is unclear why, as SARS-CoV-2 RNA is rarely detected in CSF, researchers say.

In a cross-sectional study of 44 patients with acute COVID-19 (23 with neurologic symptoms), researchers using a novel 'ultrasensitive' assay detected SARS-CoV-2 nucleocapsid antigen (N