‘Surprising’ finding in trial of resection for advanced colorectal cancer

Surgery prior to chemotherapy might not improve survival, a study suggests
Reuters Health Staff writer
suregon in theatre

Contrary to previous reports, primary tumour resection prior to chemotherapy does not appear to confer a survival benefit in people with stage IV colorectal cancer (CRC), according to results from a randomised controlled trial.

In the Japanese phase 3 trial, 165 patients from 38 centres were randomly assigned to chemotherapy alone or primary tumour resection plus chemotherapy (with either mFOLFOX6 – flurouracil, leucovorin, oxaliplatin plus bevacizumab – or CapeOX -capecitabine, oxaliplatin and bevacizumab).