'Surprising result': Higher carbidopa dose may cut Parkinson's off-time

Exploratory study suggests the 4:1 levodopa-carbidopa ratio may not be optimal

A higher dose of carbidopa, in combination with usual doses of levodopa and entacapone, can reduce ‘off-time’ in patients with fluctuating Parkinson's disease, compared with standard levodopa/carbidopa combinations, according to results from an early clinical trial.

Newsprint with Parkinson's disease highlighted

The finding casts doubt on whether the current levodopa and carbidopa ration of 4:1 is optimum, says lead researcher Dr Claudia Trenkwalder of the University Medical Centre of Goettingen, Germany.

"This is a surprising result," she said.