Tailored gynaecological surgical strategies 'beneficial' in Lynch syndrome

Australian experts say the condition may be viewed as four distinct inherited diseases

Having different strategies to reduce the risk of gynaecological cancers in women with Lynch syndrome, based on the pathogenic gene variant, would be cost-effective and associated with improved quality of life, a study shows.


The findings suggest that, for some women, a two-stage surgical approach - with oophorectomy done later -  may be the best option, the US researchers say.

The hereditary cancer syndrome is caused by germline pathogenic variants in DNA-mismatch-repair genes MLH1, MSH2, MSH6 and PMS2, but