Tailored gynaecological surgical strategies ‘beneficial’ in Lynch syndrome
Australian experts say the condition may be viewed as four distinct inherited diseases
Having different strategies to reduce the risk of gynaecological cancers in women with Lynch syndrome, based on the pathogenic gene variant, would be cost-effective and associated with improved quality of life, a study shows.
The findings suggest that, for some women, a two-stage surgical approach – with oophorectomy done later – may be the best option, the US researchers say.
The hereditary cancer syndrome is caused by germline pathogenic variants in DNA-mismatch-repair genes MLH1, MSH2, MSH6 and PMS2, but current guidance is not based on the individual gene variant.
The risks for endometrial and ovarian cancer are “high but variable” depending on genotype, the researchers note in JAMA Network Open.
