Topical calcineurin inhibitors effective for vitiligo: meta-analysis

The treatment is currently used off-label, say authors

Patients with vitiligo can be safely and effectively treated with topical calcineurin inhibitors with or without phototherapy, say authors of a systematic review and meta-analysis.


Korean researchers analysed data from 46 studies involving nearly 1500 patients to evaluate repigmentation response to treatment with topical calcineurin inhibitors (TCIs).

The primary outcomes were responses that were judged to be at least mild (at least 25%), at least moderate (50%) and marked (75%), they reported in JAMA Dermatology.

For TCI monotherapy given