Specialist Updates 
Cardiology

Two oral anticoagulants compared for effects on cognition

Head-to-head trial of warfarin and dabigatran in patients with AF
Medicom
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16 November 2021
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The oral anticoagulants warfarin and dabigatran are on a par for their effects on cognitive impairment, Brazilian researchers report.

Professor Bruno Caramelli and colleagues conducted a head-to-head comparison of the two anticoagulants in older patients with AF.

The results of the Cognitive Impairment Related to Atrial Fibrillation Prevention Trial (GIRAF) were reported to the American Heart Association Scientific Sessions 2021 virtual meeting.

The open-label, multi-centre trial included 200 Brazilian patients aged over 70 years without major cerebrovascular comorbidities, who were randomised 1:1 to dabigatran (110 or 150mg, twice daily) or warfarin (dosed for an INR of 2-3, once daily).

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