Uniform specific IgE cutoff 'arbitrary'

It’s time to determine sensitisation levels for individual aeroallergens in a large cohort, researchers say

There is no single cutoff for specific IgE that indicates clinically-relevant sensitisation to aeroallergens, researchers say.

Girl sneezing in field of flowers

The uniform cutoff of 0.35kUA/L indicating sensitisation, is based on the detection limit of early assays, write the study’s Danish authors in JAMA Pediatrics. The detection limit of newer assays is 0.1kUA/L.

The authors looked at the distribution of specific IgE levels to five common aeroallergens (house dust mites, cat,