More than half of US women who had a uterus transplant to treat uterine-factor infertility went on to have successful pregnancies, a landmark report shows.

Of the 33 women who received a uterus transplant between 2016 and 2021, a total of 19 had delivered at least one infant, clinicians say.

According to a comprehensive report on the first five years of the procedure in the US, uterus transplantation is “safe for mother and child” and the success rate “is comparable with the most effective infertility treatments”.

“For these reasons, uterus transplant should be considered a clinical reality in the US and presented as an option for individuals with [absolute uterine-factor infertility] interested in parenthood,” the authors wrote in JAMA Surgery.