Vitamin D deficiency may double risk of miscarriage: review

Observational and trial data back the importance of adequate vitamin D but give no clues on how to optimise treatment, researchers say

Pregnant women with vitamin D deficiency have a near twofold greater risk of spontaneous or recurrent miscarriage than those who are vitamin D replete, a new analysis suggests.

This association was maintained when women with “insufficient” serum 25-hydroxyvitamin D levels were included in the analysis, according to the UK investigators, with clear evidence of a “biologic gradient”.