What’s different about liver cancer linked to NAFLD?

A large systematic review characterises the main clinical features and outcomes compared with liver cancer from other causes
Fatty liver degeneration on microscopy.

Adults with non-alcoholic fatty liver disease-related hepatocellular carcinoma are less likely to have cirrhosis than those with liver cancer from other causes but are not necessarily more likely to survive, researchers say.

This patient group is also more likely to have larger tumours and uninodular lesions at diagnosis, according to a systematic review and meta-analysis claimed to be the most comprehensive international picture of the disease to date.